Precautions for use

1. Do not administer to the following patients

• 1) patients who are hypersensitive to the ingredients of this drug

2. Administer carefully to the following patients

• 1) This drug contains lactose and should not be used in patients with genetic problems of galactose intolerance, Lapp lactose deficiency, or glucose-galactose malabsorption.
• 2) This drug contains wheat starch, so patients with celiac disease need to be careful when taking.

3. Adverse reactions

• 1) Hypersensitivity may be caused to the ingredient of this drug
• 2) Depending on the patient, nosebleeds may occur and menstruation may occur again. If symptoms occur, stop taking this drug and consult a doctor or pharmacist.
• 3) Domestic post-marketing survey
  - According to the post-marketing results of 1219 patients in Korea for 4 years, the incidence of adverse events was 4.02% (49 patients / 1219 patients, 55 cases). The drug adverse reaction expression rate was 1.48% (18/1219 patients, 19 cases), menstrual disorder 0.66% (8/1219 patients, 8 cases), headache 0.25% (3/1219 patients, 3 cases), breast congestion 0.16% ( 2/1/1219, two), itching 0.16% (two / 1219, two), swelling, breast pain, nipple pain, ringworm 0.08% (one / 1219, one) There was no significant adverse drug reaction.
  - There were 11 unexpected adverse reactions, including 3 headaches, 2 breast congestion, 2 itching, swelling, breast pain, nipple pain, and ringworm. There were no significant and unexpected adverse drug reactions.

4. General precaution

• If symptoms do not improve after 12 weeks of taking, stop taking this drug and consult a doctor or pharmacist.

5. Interaction

• Interaction with other drugs has not been identified.

6. Administration to pregnant and lactating women

• Do not use during pregnancy and lactation period.

7. Storage and handling precautions

• 1) keep out of reach of children
• 2) avoid direct sunlight and store in a cool place of 15~25℃
• 3) Taking medicine out of its original container and storing it in another container may cause accidents related to drug misuse or deterioration of drug quality.